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Evolution of the immune system in humans from infancy to old age

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Item Type:Review
Title:Evolution of the immune system in humans from infancy to old age
Creators Name:Simon, A.K., Hollander, G.A. and McMichael, A.
Abstract:This article reviews the development of the immune response through neonatal, infant and adult life, including pregnancy, ending with the decline in old age. A picture emerges of a child born with an immature, innate and adaptive immune system, which matures and acquires memory as he or she grows. It then goes into decline in old age. These changes are considered alongside the risks of different types of infection, autoimmune disease and malignancy.
Keywords:Adaptive Immunity, Innate Immunity, Infections
Source:Proceedings of the Royal Society of London Series B-Biological Sciences
ISSN:0962-8452
Publisher:Royal Society
Volume:282
Number:1821
Page Range:20143085
Date:22 December 2015
Official Publication:https://doi.org/10.1098/rspb.2014.3085
PubMed:View item in PubMed

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