![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB |
![[thumbnail of Supporting Information]](https://edoc.mdc-berlin.de/style/images/fileicons/other.png) |
Other (Supporting Information)
43kB |
| Item Type: | Article |
|---|---|
| Title: | Longitudinal retinal changes in MOGAD |
| Creators Name: | Oertel, F.C., Sotirchos, E.S., Zimmermann, H.G., Motamedi, S., Specovius, S., Asseyer, E.S., Chien, C., Cook, L., Vasileiou, E., Filippatou, A., Calabresi, P.A., Saidha, S., Pandit, L., D'Cunha, A., Outteryck, O., Zéphir, H., Pittock, S., Flanagan, E.P., Bhatti, M.T., Rommer, P.S., Bsteh, G., Zrzavy, T., Kuempfel, T., Aktas, O., Ringelstein, M., Albrecht, P., Ayzenberg, I., Pakeerathan, T., Knier, B., Aly, L., Asgari, N., Soelberg, K., Marignier, R., Tilikete, C.F., Calvo, A.C., Villoslada, P., Sanchez-Dalmau, B., Martinez-Lapiscina, E.H., Llufriu, S., Green, A.J., Yeaman, M.R., Smith, T.J., Brandt, A.U., Chen, J., Paul, F. and Havla, J. |
| Abstract: | OBJECTIVE: Patients with myelin oligodendrocyte glycoprotein antibody (MOG-IgG) associated disease (MOGAD) suffer from severe optic neuritis (ON) leading to retinal neuro-axonal loss, which can be quantified by optical coherence tomography (OCT). We assessed whether ON-independent retinal atrophy can be detected in MOGAD. METHODS: Eighty MOGAD patients and 139 healthy controls (HC) were included. OCT data was acquired with 1) Spectralis spectral domain OCT (MOGAD (N=66) and HC (N=103)) and 2) Cirrus HD-OCT (MOGAD (N=14) and HC (N=36)). Macular combined ganglion cell and inner plexiform layer (GCIPL) and peripapillary retinal nerve fibre layer (pRNFL) were quantified. RESULTS: At baseline, GCIPL and pRNFL were lower in MOGAD eyes with a history of ON (MOGAD-ON) compared with MOGAD eyes without a history of ON (MOGAD-NON) and HC (p<0.001). MOGAD-NON eyes had lower GCIPL volume compared to HC (p<0.001) in the Spectralis, but not in the Cirrus cohort. Longitudinally (follow-up up to 3 years), MOGAD-ON with ON within the last 6-12 months before baseline exhibited greater pRNFL thinning than MOGAD-ON with an ON >12 months ago (p<0.001). The overall MOGAD cohort did not exhibit faster GCIPL thinning compared with HC. INTERPRETATION: Our study suggests the absence of attack-independent retinal damage in MOGAD. Yet, ongoing neuroaxonal damage or oedema resolution seems to occur for up to 12 months after ON, which is longer than what has been reported with other ON forms. These findings support that the pathomechanisms underlying optic nerve involvement and the evolution of OCT retinal changes after ON is distinct in MOGAD. This article is protected by copyright. All rights reserved. |
| Keywords: | Optical Coherence Tomography, Optic Neuritis, Myelin Oligodendrocyte Glycoprotein |
| Source: | Annals of Neurology |
| ISSN: | 0364-5134 |
| Publisher: | Wiley |
| Volume: | 92 |
| Number: | 3 |
| Page Range: | 476-485 |
| Date: | September 2022 |
| Official Publication: | https://doi.org/10.1002/ana.26440 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
