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| Item Type: | Article |
|---|---|
| Title: | Tph2 gene expression defines ethanol drinking behavior in mice |
| Creators Name: | Zaniewska, M., Mosienko, V., Bader, M. and Alenina, N. |
| Abstract: | Indirect evidence supports a link between disrupted serotonin (5-hydroxytryptamine; 5-HT) signaling in the brain and addictive behaviors. However, the effects of hyposerotonergia on ethanol drinking behavior are contradictory. In this study, mice deficient in tryptophan hydroxylase 2 (Tph2(-/-)), the rate-limiting enzyme of 5-HT synthesis in the brain, were used to assess the role of central 5-HT in alcohol drinking behavior. Life-long 5-HT depletion in these mice led to an increased ethanol consumption in comparison to wild-type animals in a two-bottle choice test. Water consumption was increased in naïve 5-HT-depleted mice. However, exposure of Tph2(-/-) animals to ethanol resulted in the normalization of water intake to the level of wild-type mice. Tph2 deficiency in mice did not interfere with ethanol-evoked antidepressant response in the forced swim test. Gene expression analysis in wild-type animals revealed no change in Tph2 expression in the brain of mice consuming ethanol compared to control mice drinking water. However, within the alcohol-drinking group, inter-individual differences in chronic ethanol intake correlated with Tph2 transcript levels. Taken together, central 5-HT is an important modulator of drinking behavior in mice but is not required for the antidepressant effects of ethanol. |
| Keywords: | Central 5-HT, Ethanol, Raphe Nuclei, Tph2 Knockout, Tph2 Transcript, Animals, Mice |
| Source: | Cells |
| ISSN: | 2073-4409 |
| Publisher: | MDPI |
| Volume: | 11 |
| Number: | 5 |
| Page Range: | 874 |
| Date: | 3 March 2022 |
| Official Publication: | https://doi.org/10.3390/cells11050874 |
| PubMed: | View item in PubMed |
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