Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Microglia form satellites with different neuronal subtypes in the adult murine central nervous system

[thumbnail of Original Article]
Preview
PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB
[thumbnail of Supporting Information] Other (Supporting Information)
5MB

Item Type:Article
Title:Microglia form satellites with different neuronal subtypes in the adult murine central nervous system
Creators Name:Bakina, O., Kettenmann, H. and Nolte, C.
Abstract:Microglia are the innate immune cells of the central nervous system (CNS). In the adult uncompromised CNS, they have a highly ramified morphology and continuously extend and retract their processes. A subpopulation of microglial cells forms close soma-to-soma contacts with neurons and have been termed satellite microglia, yet the role of such interaction is largely unknown. Here, we analyzed the distribution of satellite microglia in different areas of the CNS of adult male mice applying transgenic- and immunolabeling of neuronal subtypes and microglia followed by three-dimensional imaging analysis. We quantified satellite microglia associated with GABAergic and glutamatergic neurons in the somatosensory cortex, striatum, and thalamus; with dopaminergic and serotonergic neurons in the basal forebrain and raphe nucleus, respectively; and with cerebellar Purkinje cell neurons. Satellite microglia in the retina were assessed qualitatively. Microglia form satellites with all neuronal subtypes studied, whereas a preference for a specific neuron subtype was not found. The occurrence and frequency of satellite microglia is determined by the histo-architectural organization of the brain area and the densities of neuronal somata therein.
Keywords:Dopaminergic, GABAergic, Glutamatergic, Image Analysis, Neuron-Glia Interactions, RRID:AB_1002036, RRID:AB_11205760, RRID:AB_839504, RRID:AB_90755, RRID:IMSR_JAX:007914, RRID:IMSR_JAX:014555, RRID:IMSR_JAX:016962, RRID:IMSR_JAX:016963, RRID:MGI_3052341, RRID:SCR_003070, RRID:SCR_007370, RRID:SCR_015825, Satellite Microglia, Serotonergic, Animals, Mice
Source:Journal of Neuroscience Research
ISSN:0360-4012
Publisher:Wiley
Volume:100
Number:4
Page Range:1105-1122
Date:April 2022
Official Publication:https://doi.org/10.1002/jnr.25026
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library