GABAergic interneurons with nonlinear dendrites: from neuronal computations to memory engrams

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Item Type:	Article
Title:	GABAergic interneurons with nonlinear dendrites: from neuronal computations to memory engrams
Creators Name:	Tzilivaki, A., Kastellakis, G., Schmitz, D. and Poirazi, P.
Abstract:	GABAergic interneurons are a highly diverse class of neurons in the mammalian brain with a critical role in orchestrating multiple cognitive functions and maintaining the balance of excitation/ inhibition across neuronal circuitries. In this perspective, we discuss recent findings regarding the ability of some interneuron subtypes to integrate incoming inputs in nonlinear ways within their dendritic branches. These recently discovered features may endow the specific interneurons with advanced computing capabilities, whose breadth and functional contributions remain an open question. Along these lines, we discuss theoretical and experimental evidence regarding the potential role of nonlinear interneuron dendrites in advancing single neuron computations and contributing to memory formation.
Keywords:	Interneurons, Nonlinear Dendrites, Memory Engrams, Animals, Mammals
Source:	Neuroscience
ISSN:	0306-4522
Publisher:	Elsevier
Volume:	489
Page Range:	34-43
Date:	1 May 2022
Additional Information:	Copyright © 2022 IBRO. Published by Elsevier Ltd. All rights reserved.
Official Publication:	https://doi.org/10.1016/j.neuroscience.2021.11.033
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