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An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

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Item Type:Review
Title:An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Creators Name:Wirth, K.J., Scheibenbogen, C. and Paul, F.
Abstract:There is accumulating evidence of endothelial dysfunction, muscle and cerebral hypoperfusion in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In this paper we deduce the pathomechanisms resulting in central nervous pathology and the myriad of neurocognitive symptoms. We outline tentative mechanisms of impaired cerebral blood flow, increase in intracranial pressure and central adrenergic hyperactivity and how they can well explain the key symptoms of cognitive impairment, brain fog, headache, hypersensitivity, sleep disturbances and dysautonomia.
Keywords:Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Post-Covid-19 Syndrome, Neurological Symptoms, Cognitive Impairment, Brain Fog, Hypersensitivity, Dysautonomia, Sleep Disturbance, Headache
Source:Journal of Translational Medicine
ISSN:1479-5876
Publisher:BioMed Central
Volume:19
Number:1
Page Range:471
Date:22 November 2021
Additional Information:Erratum in: J Transl Med 20(1): 25.
Official Publication:https://doi.org/10.1186/s12967-021-03143-3
PubMed:View item in PubMed

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