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| Item Type: | Article |
|---|---|
| Title: | Reduction of cortical parvalbumin expressing GABAergic interneurons in a rodent hyperoxia model of preterm birth brain injury with deficits in social behavior and cognition |
| Creators Name: | Scheuer, T., Auf dem Brinke, E., Grosser, S., Wolf, S.A., Mattei, D., Sharkovska, Y., Barthel, P.C., Endesfelder, S., Friedrich, V., Bührer, C., Vida, I. and Schmitz, T. |
| Abstract: | The inhibitory GABAergic system in the brain is involved in the etiology of various psychiatric problems, including autism spectrum disorders (ASD), attention deficit hyperactivity disorder (ADHD), and others. These disorders are influenced not only by genetic but also by environmental factors, such as preterm birth, although the mechanisms underlying are not known. In a translational hyperoxia model, exposing mice pups at age P5 to 80% oxygen for 48 hours to mimic a steep rise of oxygen exposure caused by preterm birth from in utero into room air, we documented a persistent reduction of cortical mature parvalbumin expressing interneurons until adulthood. Developmental delay of cortical myelin was observed together with decreased expression of oligodendroglial glial cell-derived neurotrophic factor (GDNF), a factor being involved in interneuronal development. Electrophysiological and morphological properties of remaining interneurons were unaffected. Behavioral deficits were observed for social interaction, learning, and attention. These results elucidate that neonatal oxidative stress can lead to decreased interneuron density and to psychiatric symptoms. The obtained cortical myelin deficit and decreased oligodendroglial GDNF expression indicate an impaired oligodendroglial-interneuronal interplay contributes to interneuronal damage. |
| Keywords: | ADHD, ASD, Cortical Interneurons, GDNF, Oligodendroglial, Oxidative Stress, Preterm Birth, Animals, Mice |
| Source: | Development |
| ISSN: | 0950-1991 |
| Publisher: | Company of Biologists |
| Volume: | 148 |
| Number: | 20 |
| Page Range: | dev.198390 |
| Date: | October 2021 |
| Additional Information: | Copyright © 2021 The Author(s). Published by The Company of Biologists Ltd. |
| Official Publication: | https://doi.org/10.1242/dev.198390 |
| PubMed: | View item in PubMed |
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