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| Item Type: | Article |
|---|---|
| Title: | Cross-reactive CD4(+) T cells enhance SARS-CoV-2 immune responses upon infection and vaccination |
| Creators Name: | Loyal, L., Braun, J., Henze, L., Kruse, B., Dingeldey, M., Reimer, U., Kern, F., Schwarz, T., Mangold, M., Unger, C., Dörfler, F., Kadler, S., Rosowski, J., Gürcan, K., Uyar-Aydin, Z., Frentsch, M., Kurth, F., Schnatbaum, K., Eckey, M., Hippenstiel, S., Hocke, A., Müller, M.A., Sawitzki, B., Miltenyi, S., Paul, F., Mall, M.A., Wenschuh, H., Voigt, S., Drosten, C., Lauster, R., Lachman, N., Sander, L.E., Corman, V.M., Röhmel, J., Meyer-Arndt, L., Thiel, A. and Giesecke-Thiel, C. |
| Abstract: | The functional relevance of pre-existing cross-immunity to SARS-CoV-2 is a subject of intense debate. Here, we show that human endemic coronavirus (HCoV)-reactive and SARS-CoV-2-cross-reactive CD4(+) T cells are ubiquitous but decrease with age. We identified a universal immunodominant coronavirus-specific spike peptide (S816-830) and demonstrate that pre-existing spike- and S816-830-reactive T cells were recruited into immune responses to SARS-CoV-2 infection and their frequency correlated with anti-SARS-CoV-2-S1-IgG antibodies. Spike-cross-reactive T cells were also activated after primary BNT162b2 COVID-19 mRNA vaccination displaying kinetics similar to secondary immune responses. Our results highlight the functional contribution of pre-existing spike-cross-reactive T cells in SARS-CoV-2 infection and vaccination. Cross-reactive immunity may account for the unexpectedly rapid induction of immunity following primary SARS-CoV-2 immunization and the high rate of asymptomatic/mild COVID-19 disease courses. |
| Keywords: | Age Factors, Asymptomatic Diseases, CD3 Complex, CD4-Positive T-Lymphocytes, COVID-19, COVID-19 Vaccines, Coronavirus Spike Glycoprotein, Cross Reactions, Immunity, Immunodominant Epitopes, Open Reading Frames, Peptide Fragments, SARS-CoV-2, Vaccination |
| Source: | Science |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Volume: | 374 |
| Number: | 6564 |
| Page Range: | eabh1823 |
| Date: | 8 October 2021 |
| Additional Information: | This license (CCBY) does not apply to figures/photos/artwork or other content included in the article that is credited to a third party; obtain authorization from the rights holder before using such material. |
| Official Publication: | https://doi.org/10.1126/science.abh1823 |
| PubMed: | View item in PubMed |
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