Myelin-oligodendrocyte glycoprotein antibody-associated disease

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Item Type:	Article
Title:	Myelin-oligodendrocyte glycoprotein antibody-associated disease
Creators Name:	Marignier, R., Hacohen, Y., Cobo-Calvo, A., Pröbstel, A.K., Aktas, O., Alexopoulos, H., Amato, M.P., Asgari, N., Banwell, B., Bennett, J., Brilot, F., Capobianco, M., Chitnis, T., Ciccarelli, O., Deiva, K., De Sèze, J., Fujihara, K., Jacob, A., Kim, H.J., Kleiter, I., Lassmann, H., Leite, M.I., Linington, C., Meinl, E., Palace, J., Paul, F., Petzold, A., Pittock, S., Reindl, M., Sato, D.K., Selmaj, K., Siva, A., Stankoff, B., Tintore, M., Traboulsee, A., Waters, P., Waubant, E., Weinshenker, B., Derfuss, T., Vukusic, S. and Hemmer, B.
Abstract:	Myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently identified autoimmune disorder that presents in both adults and children as CNS demyelination. Although there are clinical phenotypic overlaps between MOGAD, multiple sclerosis, and aquaporin-4 antibody-associated neuromyelitis optica spectrum disorder (NMOSD) cumulative biological, clinical, and pathological evidence discriminates between these conditions. Patients should not be diagnosed with multiple sclerosis or NMOSD if they have anti-MOG antibodies in their serum. However, many questions related to the clinical characterisation of MOGAD and pathogenetic role of MOG antibodies are still unanswered. Furthermore, therapy is mainly based on standard protocols for aquaporin-4 antibody-associated NMOSD and multiple sclerosis, and more evidence is needed regarding how and when to treat patients with MOGAD.
Keywords:	Autoantibodies, Biomarkers, CNS Demyelinating Autoimmune Diseases, Immunologic Factors, Myelin-Oligodendrocyte Glycoprotein
Source:	Lancet Neurology
ISSN:	1474-4422
Publisher:	Elsevier / Lancet
Volume:	20
Number:	9
Page Range:	762-772
Date:	September 2021
Additional Information:	Erratum in: Lancet Neurol 20(10):e6. Erratum in: Lancet Neurol 21(1):e1. Copyright © 2021 Elsevier Ltd. All rights reserved.
Official Publication:	https://doi.org/10.1016/S1474-4422(21)00218-0
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