A genome-wide linkage scan for 25-OH-D(3) and 1,25-(OH)2-D3 serum levels in asthma families

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Item Type:	Article
Title:	A genome-wide linkage scan for 25-OH-D(3) and 1,25-(OH)2-D3 serum levels in asthma families
Creators Name:	Wjst, M., Altmüller, J., Braig, C., Bahnweg, M. and André, E.
Abstract:	To identify genome regions linked to serum vitamin D metabolites we analyzed 25-OH-D(3) and 1,25-(OH)(2)-D(3) levels from 947 participants of a family study recruited for asthma. From these individuals data were available from a previous genome scan that included 364 autosomal microsatellite marker. 25-OH-D(3) levels showed a heritability of 80% in these families while 1,25-(OH)(2)-D(3) reached only 30%. Genome-wide linkage using variance component analysis showed increased LOD scores for 25-OH-D(3) at marker D1S2815 (unadjusted LOD 2.9), D2S2153 (LOD 3.4), D5S2017 (LOD 2.5), D6S260 (LOD 2.1) and D17S1824 (2.5). In contrast, the maximum LOD score for 1,25-(OH)(2)-D(3) level was only 1.2 at marker D17S926. We conclude that only 25-OH-D(3) serum levels are under genetic control where several genes are involved. The lead linkage region does not code for enzymes already known in the metabolic pathway of vitamin D and may therefore contain further genes relevant to the regulation of vitamin D serum levels.
Keywords:	Calcidiol, Calcitriol, Genome Scan, CYP26B1, TGFA
Source:	Journal of Steroid Biochemistry and Molecular Biology
ISSN:	0960-0760
Publisher:	Elsevier
Volume:	103
Number:	3-5
Page Range:	799-802
Date:	March 2007
Official Publication:	https://doi.org/10.1016/j.jsbmb.2006.12.053
PubMed:	View item in PubMed

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