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| Item Type: | Article |
|---|---|
| Title: | A genome-wide linkage scan for 25-OH-D(3) and 1,25-(OH)2-D3 serum levels in asthma families |
| Creators Name: | Wjst, M., Altmüller, J., Braig, C., Bahnweg, M. and André, E. |
| Abstract: | To identify genome regions linked to serum vitamin D metabolites we analyzed 25-OH-D(3) and 1,25-(OH)(2)-D(3) levels from 947 participants of a family study recruited for asthma. From these individuals data were available from a previous genome scan that included 364 autosomal microsatellite marker. 25-OH-D(3) levels showed a heritability of 80% in these families while 1,25-(OH)(2)-D(3) reached only 30%. Genome-wide linkage using variance component analysis showed increased LOD scores for 25-OH-D(3) at marker D1S2815 (unadjusted LOD 2.9), D2S2153 (LOD 3.4), D5S2017 (LOD 2.5), D6S260 (LOD 2.1) and D17S1824 (2.5). In contrast, the maximum LOD score for 1,25-(OH)(2)-D(3) level was only 1.2 at marker D17S926. We conclude that only 25-OH-D(3) serum levels are under genetic control where several genes are involved. The lead linkage region does not code for enzymes already known in the metabolic pathway of vitamin D and may therefore contain further genes relevant to the regulation of vitamin D serum levels. |
| Keywords: | Calcidiol, Calcitriol, Genome Scan, CYP26B1, TGFA |
| Source: | Journal of Steroid Biochemistry and Molecular Biology |
| ISSN: | 0960-0760 |
| Publisher: | Elsevier |
| Volume: | 103 |
| Number: | 3-5 |
| Page Range: | 799-802 |
| Date: | March 2007 |
| Official Publication: | https://doi.org/10.1016/j.jsbmb.2006.12.053 |
| PubMed: | View item in PubMed |
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