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| Item Type: | Article |
|---|---|
| Title: | Reduction of tissue Na(+) accumulation after renal transplantation |
| Creators Name: | Dahlmann, A., Linz, P., Zucker, I., Haag, V., Jantsch, J., Dienemann, T., Nagel, A.M., Neubert, P., Rosenhauer, D., Rauh, M., Horn, S., Müller, D.N., Schiffer, M., Luft, F.C., Uder, M. and Kopp, C. |
| Abstract: | INTRODUCTION: Chronic kidney disease (CKD) engenders salt-sensitive hypertension. Whether or not tissue Na(+) accumulation is increased in CKD patients remains uncertain. How tissue Na(+) is affected after renal transplantation has not been assessed. METHODS: We measured tissue Na(+) amount in 31 CKD patients (stage 5) and prospectively evaluated tissue Na(+) content at 3 and 6 months, following living-donor kidney transplantation. Additionally, pre- and post-transplantation data were compared to 31 age- and sex-matched control subjects. (23)Na–magnetic resonance imaging ((23)Na-MRI) was used to quantify muscle and skin Na(+) of the lower leg and water distribution was assessed by bioimpedance spectroscopy. RESULTS: Compared to control subjects, CKD patients showed increased muscle (20.7 ± 5.0 vs. 15.5 ± 1.8 arbitrary units [a.u.], P < 0.001) and skin Na+ content (21.4 ± 7.7 vs. 15.0 ± 2.3 a.u., P < 0.001), whereas plasma Na(+) concentration did not differ between groups. Restoration of kidney function by successful renal transplantation was accompanied by mobilization of tissue Na(+) from muscle (20.7 ± 5.0 vs. 16.8 ± 2.8 a.u., P < 0.001) and skin tissue (21.4 ± 7.7 vs. 16.8 ± 5.2 a.u., P < 0.001). The reduction of tissue Na(+) after transplantation was associated with improved renal function, normalization of blood pressure as well as an increase in lymphatic growth-factor concentration (vascular endothelial growth factor C [VEGF-C] 4.5 ± 1.8 vs. 6.7 ± 2.7 ng/ml, P < 0.01). CONCLUSIONS: Tissue Na+ accumulation in predialysis patients with CKD was almost completely reversed to the level of healthy controls after successful kidney transplantation. |
| Keywords: | Chronic Kidney Disease, Kidney Transplantation, Tissue Na(+), (23)Na–Magnetic Resonance Imaging, Vascular Endothelial Growth Factor C |
| Source: | Kidney International Reports |
| ISSN: | 2468-0249 |
| Publisher: | Elsevier |
| Volume: | 6 |
| Number: | 9 |
| Page Range: | 2338-2347 |
| Date: | September 2021 |
| Official Publication: | https://doi.org/10.1016/j.ekir.2021.06.022 |
| PubMed: | View item in PubMed |
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