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Mitochondria in neurogenesis: implications for mitochondrial diseases

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Item Type:Article
Title:Mitochondria in neurogenesis: implications for mitochondrial diseases
Creators Name:Brunetti, D., Dykstra, W., Le, S., Zink, A. and Prigione, A.
Abstract:Mitochondria are organelles with recognized key roles in cellular homeostasis, including bioenergetics, redox, calcium signaling, and cell death. Mitochondria are essential for neuronal function, given the high energy demands of the human brain. Consequently, mitochondrial diseases affecting oxidative phosphorylation (OXPHOS) commonly exhibit neurological impairment. Emerging evidence suggests that mitochondria are important not only for mature postmitotic neurons but also for the regulation of neural progenitor cells (NPCs) during the process of neurogenesis. These recent findings put mitochondria as central regulator of cell fate decisions during brain development. OXPHOS mutations may disrupt the function of NPCs and thereby impair the metabolic programming required for neural fate commitment. Promoting the mitochondrial function of NPCs could therefore represent a novel interventional approach against incurable mitochondrial diseases.
Keywords:iPSCs, Mitochondria, Mitochondrial Diseases, Neurogenesis, NPCs
Source:Stem Cells
ISSN:1066-5099
Publisher:Wiley
Volume:39
Number:10
Page Range:1289-1297
Date:October 2021
Official Publication:https://doi.org/10.1002/stem.3425
PubMed:View item in PubMed

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