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| Item Type: | Article |
|---|---|
| Title: | AQP4-IgG autoimmunity in Japan and Germany: differences in clinical profiles and prognosis in seropositive neuromyelitis optica spectrum disorders |
| Creators Name: | Asseyer, S., Masuda, H., Mori, M., Bellmann-Strobl, J., Ruprecht, K., Siebert, N., Cooper, G., Chien, C., Duchow, A., Schließeit, J., Liu, J., Sugimoto, K., Uzawa, A., Ohtani, R., Paul, F., Brandt, A.U., Kuwabara, S. and Zimmermann, H.G. |
| Abstract: | BACKGROUND: Clinical outcomes in neuromyelitis optica spectrum disorders (NMOSD) vary across different regions. OBJECTIVE: To describe clinical profiles in Japanese and German NMOSD patients. METHODS: Medical records of aquaporin-4-immunoglobulin G (AQP4-IgG) positive NMOSD patients from Japan (n = 54) and Germany (n = 38) were retrospectively analyzed. RESULTS: The disability status was similar between both cohorts, although Japanese patients had a longer disease duration (13.3 ± 11.1 vs. 8.1 ± 6.9 years, p = 0.018) but similar relapse rates. Optic neuritis and myelitis were the most frequent attacks in both cohorts. Brain attacks occurred more frequently in Japanese patients (40.7% vs. 15.8%, p = 0.020). The time from disease onset (median [interquartile range] 2.3 [0.3-10.1] vs. 0.6 [0.2-1.9] years, p = 0.009) and the number of attacks (2.5 [1-7] vs. 2 [1-3], p = 0.047) until start of the first immunotherapy were higher in the Japanese cohort. Rituximab was the most common drug in the German cohort (52.6%) and not given in the Japanese cohort (p < 0.001), where oral prednisolone was the most common drug (92.6% vs. 15.8%, p < 0.001). The frequency of autoimmune comorbidities was higher in the German cohort (39.5% vs. 18.5%, p = 0.047). CONCLUSION: Compared with Japanese NMOSD patients, German patients presented with similar disability despite shorter disease duration and earlier and more frequent immunosuppressive therapy. |
| Keywords: | Anti-Aquaporin 4 Antibodies, Autoimmune Diseases, Ethnicity, Immunotherapy, Neuromyelitisoptica Spectrum Disorders |
| Source: | Multiple Sclerosis Journal Experimental Translational and Clinical |
| ISSN: | 2055-2173 |
| Publisher: | Sage Publications |
| Volume: | 7 |
| Number: | 2 |
| Page Range: | 205521732110068 |
| Date: | 1 April 2021 |
| Official Publication: | https://doi.org/10.1177/20552173211006862 |
| PubMed: | View item in PubMed |
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