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| Item Type: | Article |
|---|---|
| Title: | Longitudinal analysis of T1w/T2w ratio in patients with multiple sclerosis from first clinical presentation |
| Creators Name: | Cooper, G., Chien, C., Zimmermann, H., Bellmann-Strobl, J., Ruprecht, K., Kuchling, J., Asseyer, S., Brandt, A.U., Scheel, M., Finke, C. and Paul, F. |
| Abstract: | BACKGROUND: Cross-sectional studies suggest normal appearing white matter (NAWM) integrity loss may lead to cortical atrophy in late-stage relapsing-remitting multiple sclerosis (MS). OBJECTIVE: To investigate the relationship between NAWM integrity and cortical thickness from first clinical presentation longitudinally. METHODS: NAWM integrity and cortical thickness were assessed with 3T magnetic resonance imaging (MRI) in 102 patients with clinically isolated syndrome or early MS (33.2 (20.1–60.1) years old, 68% female) from first clinical presentation over 2.8 ± 1.6 years. Fifty healthy controls (HCs) matched for age and sex were included. NAWM integrity was evaluated using the standardized T1w/T2w ratio (sT1w/T2w). The association between sT1w/T2w and cortical thickness was assessed using linear mixed models. The effect of disease activity was investigated using the No Evidence of Disease Activity (NEDA-3) criteria. RESULTS: At baseline, sT1w/T2w (p = 0.152) and cortical thickness (p = 0.489) did not differ from HCs. Longitudinally, decreasing sT1w/T2w was associated with cortical thickness and increasing lesion burden (marginal R(2) = 0.061). The association was modulated by failing NEDA-3 (marginal R(2) = 0.097). CONCLUSION: sT1w/T2w may be a useful MRI biomarker for early MS, detecting relevant NAWM damage over time using conventional MRI scans, although with less sensitivity compared to quantitative measures. |
| Keywords: | T1w/T2w Ratio, Multiple Sclerosis, Normal Appearing White Matter Damage, Cortical Thickness, Longitudinal Analysis, NEDA-3 |
| Source: | Multiple Sclerosis Journal |
| ISSN: | 1352-4585 |
| Publisher: | Sage Publications |
| Volume: | 27 |
| Number: | 14 |
| Page Range: | 2180-2190 |
| Date: | December 2021 |
| Official Publication: | https://doi.org/10.1177/13524585211003479 |
| PubMed: | View item in PubMed |
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