Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Rabies anterograde monosynaptic tracing reveals organization of spinal sensory circuits

[thumbnail of Preprint]
Preview
PDF (Preprint) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
29MB
[thumbnail of Supplementary Material] Other (Supplementary Material)
31MB
Item Type:Preprint
Title:Rabies anterograde monosynaptic tracing reveals organization of spinal sensory circuits
Creators Name:Pimpinella, S. and Zampieri, N.
Abstract:Somatosensory neurons detect vital information about the environment and internal status of the body, such as temperature, touch, itch and proprioception. The circuit mechanisms controlling the coding of somatosensory information and the generation of appropriate behavioral responses are not clear yet. In order to address this issue, it is important to define the precise connectivity patterns between primary sensory afferents dedicated to the detection of different stimuli and recipient neurons in the central nervous system. In this study we used a rabies tracing approach for mapping spinal circuits receiving sensory input from distinct, genetically defined, modalities. We analyzed the anatomical organization of spinal circuits involved in coding of thermal and mechanical stimuli and showed that somatosensory information from distinct modalities is relayed to partially overlapping ensembles of interneurons displaying stereotyped laminar organization, thus highlighting the importance of positional features and population coding for the processing and integration of somatosensory information.
Keywords:Animals, Mice
Source:bioRxiv
Publisher:Cold Spring Harbor Laboratory Press
Article Number:429920
Date:11 February 2021
Official Publication:https://doi.org/10.1101/2021.02.11.429920

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library