Hyponatriämie - Ursachen, Diagnostik und Therapie [Hyponatremia - causes, diagnostic evaluation and treatment]

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Item Type:	Article
Title:	Hyponatriämie - Ursachen, Diagnostik und Therapie [Hyponatremia - causes, diagnostic evaluation and treatment]
Creators Name:	Kettritz, R.
Abstract:	Intact osmoregulation prevents osmotic gradients thereby limiting cell swelling and shrinking. Hyponatremia is a state of an osmole-free water excess compared to the amounts of solutes and clinical management of hyponatremic patients requires pathophysiology-oriented approaches to select appropriate treatments. Clinicians need to assess the patient's volume status to differentiate hyponatremia with volume depletion, expansion or normovolemia, respectively. In addition, work-up includes differentiation between acute and chronic and asymptomatic and symptomatic hyponatremia. Estimation of free water-clearance helps predicting Serum-Na(+) changes and is important to prevent overcorrection of hyponatremia. Water restriction, hypertonic salt, urea, V2-receptor-blockers and recently sodium glucose cotransporter 2 (SGLT2) inhibitors were employed to treat patients with hyponatremia.
Keywords:	Hyponatremia, Osmolarity, Water, Pathophysiology, Treatment
Source:	Deutsche Medizinische Wochenschrift
ISSN:	0012-0472
Publisher:	Thieme
Volume:	146
Number:	3
Page Range:	176-180
Date:	February 2021
Official Publication:	https://doi.org/10.1055/a-1198-3814
PubMed:	View item in PubMed

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