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Quantitative assessment of renal perfusion and oxygenation by invasive probes: basic concepts

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Item Type:Article
Title:Quantitative assessment of renal perfusion and oxygenation by invasive probes: basic concepts
Creators Name:Cantow, K., Evans, R.G., Grosenick, D., Gladytz, T., Niendorf, T., Flemming, B. and Seeliger, E.
Abstract:Renal tissue hypoperfusion and hypoxia are early key elements in the pathophysiology of acute kidney injury of various origins, and may also promote progression from acute injury to chronic kidney disease. Here we describe basic principles of methodology to quantify renal hemodynamics and tissue oxygenation by means of invasive probes in experimental animals. Advantages and disadvantages of the various methods are discussed in the context of the heterogeneity of renal tissue perfusion and oxygenation.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by a separate chapter describing the experimental procedure and data analysis.
Keywords:Renal Hemodynamics and Oxygenation, In Vivo Methods, Quantitative Invasive Probes, Animals
Source:Methods in Molecular Biology
Series Name:Methods in Molecular Biology
Title of Book:Preclinical MRI of the kidney : methods and protocols
ISSN:1064-3745
ISBN:978-1-0716-0977-4
Publisher:Springer / Humana Press
Volume:2216
Page Range:89-107
Date:2021
Official Publication:https://doi.org/10.1007/978-1-0716-0978-1_6
PubMed:View item in PubMed
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