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| Item Type: | Article |
|---|---|
| Title: | Effects of a new combination of nutraceuticals with Morus alba on lipid profile, insulin sensitivity and endotelial function in dyslipidemic subjects. A cross-over, randomized, double-blind trial |
| Creators Name: | Trimarco, V., Izzo, R., Stabile, E., Rozza, F., Santoro, M., Manzi, M.V., Serino, F., Schiattarella, G.G., Esposito, G. and Trimarco, B. |
| Abstract: | INTRODUCTION: Nutraceuticals (NUT) are forms of compounds with biological activity commonly used to improve health in dosage largely exceeding those obtainable in food. AIM: We compared, in a double blind randomized cross-over trial, the effects of two NUT combinations on the control of glico-lipidic metabolism in patients with hypercholesterolemia not on statins. METHODS: At study start patients were given dietary counseling and received placebo for 2 weeks. After this run-in period, patients were randomized: (1) Combination A [Policosanol, Red yeast rice (Monakolin K 3 mg), Berberine 500 mg, Astaxantine, Folic Acid and Coenzyme Q10] for 4 weeks followed by 4 weeks of Combination B [Red yeast rice (Monakolin K 3.3 mg), Berberine 531.25 mg and leaf extract of Morus alba]; (2) Combination B for 4 weeks followed by 4 weeks of Combination A. RESULTS: Combination B reduced LDL cholesterol below 130 mg/dl in 56.5 % of the patients, and Cambination A only in 21.7 % of them (p ≤ 0.027). Both treatments reduced plasma levels of triglycerides, total and LDL cholesterol and increased HDL cholesterol (all p < 0.03). Total and LDL cholesterol reduction was more pronounced in patients taking Combination B (p < 0.005). Combination B reduced also glycated hemoglobin, fasting glucose and insulin plasma levels as well as HOMA index (p < 0.005). CONCLUSIONS: An increased content of Berberin and Monacolin K and the addition of Morus alba extract improves the effect on plasma cholesterol and on glucose metabolism of the NUT Combination. These effects may allow the speculation of a more marked improvement in cardiovascular prognosis. |
| Keywords: | Nutraceuticals, Hypercholesterolemia, Insulin Sensitivity |
| Source: | High Blood Pressure & Cardiovascular Prevention |
| ISSN: | 1179-1985 |
| Publisher: | Springer |
| Volume: | 22 |
| Number: | 2 |
| Page Range: | 149-154 |
| Date: | June 2015 |
| Official Publication: | https://doi.org/10.1007/s40292-015-0087-2 |
| PubMed: | View item in PubMed |
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