Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Novel molecular approaches in heart failure: seven trans-membrane receptors signaling in the heart and circulating blood leukocytes

[thumbnail of Original Article]
Preview
PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
507kB

Item Type:Review
Title:Novel molecular approaches in heart failure: seven trans-membrane receptors signaling in the heart and circulating blood leukocytes
Creators Name:Schiattarella, G.G., Magliulo, F., Cattaneo, F., Gargiulo, G., Sannino, A., Franzone, A., Oliveti, M., Perrino, C., Trimarco, B. and Esposito, G.
Abstract:Heart failure (HF) is the result of molecular, cellular, and structural changes induced by cardiac load or injury. A complex network of signaling pathways have been involved in the development and progression of cardiac dysfunction. In this review, we summarize the pivotal role of seven trans-membrane receptors (7TMRs), also called G-protein-coupled receptors (GPCRs), in HF. Moreover, we will discuss the current knowledge on the potential mirroring of 7TMR signaling between circulating blood leukocytes and the heart, and the related future possibilities in the management of HF patients.
Keywords:Cardiac Remodeling, Seven Trans-Membrane Receptors, Leukocytes, Heart Failure
Source:Frontiers in Cardiovascular Medicine
ISSN:2297-055X
Publisher:Frontiers Media SA
Volume:2
Page Range:13
Date:16 March 2015
Official Publication:https://doi.org/10.3389/fcvm.2015.00013
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library