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The ARTS of cell death

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Item Type:Comment
Title:The ARTS of cell death
Creators Name:Koren, E. and Fuchs, Y.
Abstract:Although much is known regarding intestinal stem cell (ISC) self-renewal and differentiation, the specific mechanisms used for their elimination is unclear. We recently discovered that the pro-apoptotic protein ARTS, a Septin4 isoform, interacts with X-linked inhibitor of apoptosis (XIAP) in the ISC niche to regulate stem cell survival during intestinal homeostasis and regeneration. These findings point to an intriguing avenue of translational research, examining how manipulation of stem cell apoptosis through the ARTS/XIAP module can affect stem-cell-dependent processes.
Keywords:Apoptosis, ARTS, XIAP, Stem Cells, Paneth Cells, Wnt Pathway, Regeneration
Source:Journal of Cell Death
ISSN:1179-0660
Publisher:Sage Publishing
Volume:12
Page Range:1179066019836967
Date:1 January 2019
Official Publication:https://doi.org/10.1177/1179066019836967
PubMed:View item in PubMed

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