Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

CoBold: a method for identifying different functional classes of transient RNA structure features that can impact RNA structure formation in vivo

[thumbnail of Original Article]
Preview
PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
6MB
[thumbnail of Supplementary Data]
Preview
PDF (Supplementary Data) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
32MB

Item Type:Article
Title:CoBold: a method for identifying different functional classes of transient RNA structure features that can impact RNA structure formation in vivo
Creators Name:Martín, A.L., Mounir, M. and Meyer, I.M.
Abstract:RNA structure formation in vivo happens co-transcriptionally while the transcript is being made. The corresponding co-transcriptional folding pathway typically involves transient RNA structure features that are not part of the final, functional RNA structure. These transient features can play important functional roles of their own and also influence the formation of the final RNA structure in vivo. We here present CoBold, a computational method for identifying different functional classes of transient RNA structure features that can either aid or hinder the formation of a known reference RNA structure. Our method takes as input either a single RNA or a corresponding multiple-sequence alignment as well as a known reference RNA secondary structure and identifies different classes of transient RNA structure features that could aid or prevent the formation of the given RNA structure. We make CoBold available via a web-server which includes dedicated data visualisation.
Keywords:5' Untranslated Regions, Catalytic RNA, Computational Biology, Genetic Transcription, Molecular Evolution, Nucleic Acid Conformation, RNA, RNA Folding, RNA Sequence Analysis, Riboswitch, Sequence Alignment, Software
Source:Nucleic Acids Research
ISSN:0305-1048
Publisher:Oxford University Press
Volume:49
Number:4
Page Range:e19
Date:26 February 2021
Official Publication:https://doi.org/10.1093/nar/gkaa900
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library