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Karzinogenese: Big Bang oder kontinuierliche Evolution?

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Item Type:Review
Title:Karzinogenese: Big Bang oder kontinuierliche Evolution?
Creators Name:Haase, K. and Schwarz, R.F.
Abstract:Intra-tumour heterogeneity is a key characteristic of tumours and poses significant clinical challenges. Despite extensive research, the evolutionary processes shaping cancer genomes are not yet fully understood. We here discuss two conflicting theories about the evolution of solid tumours: the Big Bang model and the classical model of continuous evolution. Using chromosomal instability we shed light on the preferred mode of cancer evolution and its implications for personalised treatment.
Source:BIOspektrum
ISSN:0947-0867
Publisher:Springer / Spektrum Akademischer Verlag
Volume:26
Number:7
Page Range:718-720
Date:November 2020
Additional Information:Erratum in: BIOspektrum 27(1): 37.
Official Publication:https://doi.org/10.1007/s12268-020-1488-x

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