Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

The CAR group of Ig cell adhesion proteins - regulators of gap junctions?

[thumbnail of Original Article]
Preview
PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
5MB

Item Type:Article
Title:The CAR group of Ig cell adhesion proteins - regulators of gap junctions?
Creators Name:Rathjen, F.G.
Abstract:Members of the CAR group of Ig‐like type I transmembrane proteins mediate homotypic cell adhesion, share a common overall extracellular domain structure and are closely related at the amino acid sequence level. CAR proteins are often found at tight junctions and interact with intracellular scaffolding proteins, suggesting that they might modulate tight junction assembly or function. However, impairment of tight junction integrity has not been reported in mouse knockout models or zebrafish mutants of CAR members. In contrast, in the same knockout models deficits in gap junction communication were detected in several organ systems, including the atrioventricular node of the heart, smooth muscle cells of the intestine and the ureter and in Sertoli cells of the testes. Possible interactions between BT‐IgSF and connexin41.8 on the disturbed pattern of pigment stripes found in zebrafish mutants and between ESAM and connexin43 during hematopoiesis in the mouse are also discussed. On the basis of the combined data and phenotypic similarities between CAR member mutants and connexin mutants I hypothesize that they primarily play a role in the organization of gap junction communication.
Keywords:BT-IgSF (IgSF11), CAR, CLMP, Connexins, ESAM, Gap Junctions, IgCAMs, Animals, Mice, Zebrafish
Source:BioEssays
ISSN:0265-9247
Publisher:Wiley
Volume:42
Number:12
Page Range:e2000031
Date:December 2020
Official Publication:https://doi.org/10.1002/bies.202000031
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library