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| Item Type: | Article |
|---|---|
| Title: | Stress hormones or general well-being are not altered in immune-deficient mice lacking either T- and B- lymphocytes or Interferon gamma signaling if kept under specific pathogen free housing conditions |
| Creators Name: | Jeuthe, S., Kemna, J., Kemna, C.P., Zocholl, D., Klopfleisch, R., Palme, R., Kirschbaum, C., Thoene-Reineke, C. and Kammertoens, T. |
| Abstract: | It is controversially discussed whether immune-deficient mice experience severity in the absence of infection. Because a comprehensive analysis of the well-being of immune-deficient mice under specific pathogen free conditions is missing, we used a multi-parametric test analyzing, corticosterone, weight, nest building and facial expression over a period of 9 month to determine the well-being of two immune-deficient mouse lines (recombination activating gene 2- and interferon gamma receptor-deficient mice). We do not find evidence for severity when comparing immune-deficient mice to their heterozygous immune-competent littermates. Our data challenge the assumption that immune-deficiency per se regardless of housing conditions causes severity. Based on our study we propose to use objective non-invasive parameters determined by laboratory animal science for decisions concerning severity of immune-deficient mice. |
| Keywords: | B-Lymphocytes, Corticosterone, DNA-Binding Proteins, Infections, Interferon Receptors, Interferon-gamma, Kidney, Pain, SCID Mice, Signal Transduction, T-Lymphocytes, Testosterone, Animals, Mice |
| Source: | PLoS ONE |
| ISSN: | 1932-6203 |
| Publisher: | Public Library of Science |
| Volume: | 15 |
| Number: | 9 |
| Page Range: | e0239231 |
| Date: | 30 September 2020 |
| Official Publication: | https://doi.org/10.1371/journal.pone.0239231 |
| PubMed: | View item in PubMed |
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