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| Item Type: | Article |
|---|---|
| Title: | Long-lived tumor-associated macrophages in glioma |
| Creators Name: | Georgieva, P.B., Mathivet, T., Alt, S., Giese, W., Riva, M., Balcer, M. and Gerhardt, H. |
| Abstract: | BACKGROUND: The tumor microenvironment (TME) plays a major tumor-supportive role in glioma. In particular, tumor-associated macrophages (TAMs), which can make up to one third of the tumor mass, actively support tumor growth, invasion and angiogenesis. Predominantly alternatively activated (M2-polarized) TAMs are found in late stage glioma in both human and mouse tumors, as well as in relapse samples from patients. However, whether tumor-educated M2 TAMs can actively contribute to the emergence and growth of relapse is currently debated. METHODS: To investigate whether tumor-educated stromal cells remaining in the brain after surgical removal of the primary tumor can be long-lived and retain their tumor-supporting function, we developed a transplantation mouse model and performed lineage-tracing. RESULTS: We discovered that macrophages can survive transplantation and stay present in the tumor much longer than previously suggested, while sustaining an M2 polarized pro-tumorigenic phenotype. Transplanted tumors showed a more aggressive growth and faster polarization of the TAMs toward an M2 phenotype compared to primary tumors, a process dependent on the presence of few co-transplanted macrophages. CONCLUSIONS: Overall, we propose a new way for tumor-educated TAMs to contribute to glioma aggressiveness by long survival and stable pro-tumorigenic features. These properties could have a relapse-supporting effect. |
| Keywords: | Glioma, Tumor-Associated Macrophages, Tumor Transplantation, Long-Lived Macrophages, Tumor Microenvironment, Animals, Mice |
| Source: | Neuro-Oncology Advances |
| ISSN: | 2632-2498 |
| Publisher: | Oxford University Press |
| Volume: | 2 |
| Number: | 1 |
| Page Range: | vdaa127 |
| Date: | 9 November 2020 |
| Additional Information: | Copyright © The Author(s) 2020. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| Official Publication: | https://doi.org/10.1093/noajnl/vdaa127 |
| PubMed: | View item in PubMed |
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