![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
4MB |
Preview |
PDF (Supplementary Materials)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
8MB |
| Item Type: | Article |
|---|---|
| Title: | N-acetylglucosamine drives myelination by triggering oligodendrocyte precursor cell differentiation |
| Creators Name: | Sy, M., Brandt, A.U., Lee, S.U., Newton, B. L., Pawling, J., Golzar, A., Rahman, A.A., Yu, Z., Cooper, G., Scheel, M., Paul, F., Dennis, J.W. and Demetriou, M. |
| Abstract: | Myelination plays an important role in cognitive development and in demyelinating diseases like multiple sclerosis (MS), where failure of re-myelination promotes permanent neuro-axonal damage. Modification of cell surface receptors with branched N-glycans coordinates cell growth and differentiation by controlling glycoprotein clustering, signaling and endocytosis. N-acetylglucosamine (GlcNAc) is a rate-limiting metabolite for N-glycan branching. Here we report that GlcNAc and N-glycan branching trigger oligodendrogenesis from precursor cells by inhibiting PDGF receptor-α cell endocytosis. Supplying oral GlcNAc to lactating mice drives primary myelination in newborn pups via secretion in breast milk, while genetically blocking N-glycan branching markedly inhibits primary myelination. In adult mice with toxin (cuprizone) induced demyelination, oral GlcNAc prevents neuro-axonal damage by driving myelin repair. In MS patients, endogenous serum GlcNAc levels inversely correlated with imaging measures of demyelination and microstructural damage. Our data identifies N-glycan branching and GlcNAc as critical regulators of primary myelination and myelin repair and suggests oral GlcNAc may be neuro-protective in demyelinating diseases like MS. |
| Keywords: | N-glycan Branching, N-acetylglucosamine, Oligodendrocytes, Myelination, Myelin Repair, Multiple Sclerosis, Animals, Mice |
| Source: | Journal of Biological Chemistry |
| ISSN: | 0021-9258 |
| Publisher: | American Society for Biochemistry and Molecular Biology |
| Volume: | 295 |
| Number: | 51 |
| Page Range: | 17413-17424 |
| Date: | 18 December 2020 |
| Official Publication: | https://doi.org/10.1074/jbc.RA120.015595 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
