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Emerging roles of SIRT1 in vascular endothelial homeostasis

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Item Type:Article
Title:Emerging roles of SIRT1 in vascular endothelial homeostasis
Creators Name:Potente, M. and Dimmeler, S.
Abstract:Sir2 is a NAD(+)-dependent deacetylase, which regulates life span in multiple model organisms in response to caloric restriction. Mammalian homologues of Sir2 comprise a family of seven proteins termed sirtuins (SIRT1-SIRT7), which have gained considerable attention for their impact on several important physiological processes associated with metabolism and stress resistance. In addition, recent studies point to SIRT1 as a key regulator of vascular endothelial homeostasis controlling angiogenesis, vascular tone and endothelial dysfunction. Here, we review the emerging role of SIRT1 as an important modulator of signaling networks critical for maintaining vascular endothelial homeostasis and discuss SIRT1 as a potential therapeutic target for cardiovascular diseases in the adult.
Keywords:Angiogenesis, Endothelial Cells, HDAC, Sirtuins, Animals
Source:Cell Cycle
ISSN:1538-4101
Publisher:Taylor & Francis
Volume:7
Number:14
Page Range:2117-2122
Date:15 July 2008
Official Publication:https://doi.org/10.4161/cc.7.14.6267
PubMed:View item in PubMed

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