Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils

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Item Type:	Article
Title:	Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils
Creators Name:	Cerofolini, L., Ravera, E., Bologna, S., Wiglenda, T., Böddrich, A., Purfürst, B., Benilova, I., Korsak, M., Gallo, G., Rizzo, D., Gonnelli, L., Fragai, M., De Strooper, B., Wanker, E.E. and Luchinat, C.
Abstract:	Recent structural studies show distinct morphologies for the fibrilsof Ab(1-42) and Ab(1-40), which are believed not to co-fibrillize.We describe here a novel, structurally-uniform 1 : 1 mixed fibrillarspecies, which differs from bothpure fibrils. It forms preferen-tially even when Ab(1-42) : Ab(1-40) peptides are mixed in a non-stoichiometric ratio.
Keywords:	Amyloid beta-Peptides, Molecular Models, Peptide Fragments, Protein Aggregates, Secondary Protein Structure
Source:	Chemical Communications
ISSN:	1359-7345
Publisher:	Royal Society of Chemistry
Volume:	56
Number:	62
Page Range:	8830-8833
Date:	11 August 2020
Official Publication:	https://doi.org/10.1039/d0cc02463e
PubMed:	View item in PubMed

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