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| Item Type: | Article |
|---|---|
| Title: | Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas |
| Creators Name: | Arnold, A., Daum, S., von Winterfeld, M., Berg, E., Hummel, M., Rau, B., Stein, U. and Treese, C. |
| Abstract: | INTRODUCTION: The tight junction molecule Claudin 18.2 is selectively expressed in healthy and malignant gastric epithelial tissue and is a promising therapy target for high Claudin 18.2 expressing adenocarcinomas of the esophagogastric junction and stomach (AEG/S). METHODS: This study analyzed the prevalence, characteristics and prognostic impact of Claudin 18.2 expression in primary tumor, lymph node and distant metastasis in a large Caucasian AGE/S cohort with 414 patients. RESULTS: Claudin 18.2 was highly expressed in 17.1% of primary tumors, 26.7% of lymph node metastasis and 16.7% of distant metastasis. High Claudin 18.2 expression in lymph node metastasis and primary tumors correlated significantly (p < 0.001). High expression of Claudin 18.2 was neither associated with histomorphogical subtype, or tumor state, nor with overall survival. CONCLUSION: In Caucasian AEG/S patients, 17.1% appeared to be eligible for an anti-Claudin 18.2 therapy. Claudin 18.2 expression itself has no impact on prognosis and is not related to any tumor subtype. |
| Keywords: | Claudin 18.2, Claudiximab, IMAB362, Gastric Cancer, Esophageal Cancer |
| Source: | Clinical and Translational Oncology |
| ISSN: | 1699-048X |
| Publisher: | Springer |
| Volume: | 22 |
| Number: | 12 |
| Page Range: | 2357-2363 |
| Date: | December 2020 |
| Official Publication: | https://doi.org/10.1007/s12094-020-02380-0 |
| PubMed: | View item in PubMed |
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