CXCR4-targeted PET imaging of central nervous system B-cell lymphoma

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Item Type:	Article
Title:	CXCR4-targeted PET imaging of central nervous system B-cell lymphoma
Creators Name:	Herhaus, P., Lipkova, J., Lammer, F., Yakushev, I., Vag, T., Slotta-Huspenina, J., Habringer, S., Lapa, C., Pukrop, T., Hellwig, D., Wiestler, B., Buck, A.K., Deckert, M., Wester, H.J., Bassermann, F., Schwaiger, M., Weber, W.A., Menze, B. and Keller, U.
Abstract:	C-X-C chemokine receptor 4 is a transmembrane chemokine receptor involved in growth, survival, and dissemination of cancer, including aggressive B-cell lymphoma. Magnetic resonance imaging (MRI) is the standard imaging technology for central nervous system involvement of B-cell lymphoma and provides high sensitivity but moderate specificity. Therefore, novel molecular and functional imaging strategies are urgently required. METHODS: In this proof-of-concept study, 11 patients with lymphoma of the CNS (CNSL, n = 8 primary and n = 3 secondary involvement) were imaged with the CXCR4-directed positron emission tomography (PET) tracer (68)Ga-Pentixafor. To evaluate the predictive value of this imaging modality, treatment response, as determined by MRI, was correlated with quantification of CXCR4 expression by (68)Ga-Pentixafor PET in vivo before initiation of treatment in 7 of 11 patients. RESULTS: (68)Ga-Pentixafor-PET showed excellent contrast characteristics to the surrounding brain parenchyma in all patients with active disease. Furthermore, initial CXCR4 uptake determined by PET correlated with subsequent treatment response as assessed by MRI. CONCLUSION: (68)Ga-Pentixafor-PET represents a novel diagnostic tool for central nervous system lymphoma with potential implications for theranostic approaches as well as response and risk assessment.
Keywords:	Central Nervous System Lymphoma, CXCR4, In Vivo Imaging, PET, MRI
Source:	Journal of Nuclear Medicine
ISSN:	0161-5505
Publisher:	Society of Nuclear Medicine
Volume:	61
Number:	12
Page Range:	1765-1771
Date:	1 December 2020
Official Publication:	https://doi.org/10.2967/jnumed.120.241703
PubMed:	View item in PubMed

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