Binding patterns and functional properties of human antibodies to AQP4 and MOG on murine optic nerve and retina

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Item Type:	Article
Title:	Binding patterns and functional properties of human antibodies to AQP4 and MOG on murine optic nerve and retina
Creators Name:	Faissner, S., Graz, F., Reinehr, S., Petrikowski, L., Haupeltshofer, S., Ceylan, U., Stute, G., Winklmeier, S., Pache, F., Paul, F., Ruprecht, K., Meinl, E., Dick, H.B., Gold, R., Kleiter, I. and Joachim, S.C.
Abstract:	Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-inflammatory CNS disease affecting spinal cord and optic nerves, mediated by autoantibodies against aquaporin-4 (AQP4) and myelin-oligodendrocyte-glycoprotein (MOG). Effects of those immunoglobulins (Ig) on retina and optic nerve are incompletely understood. We investigated AQP4-IgG and MOG-IgG sera on retina and optic nerve ex vivo and in 2D2 mice, which harbor a transgenic MOG-specific T-cell receptor. Some sera reacted with murine retina and optic nerve showing distinct binding patterns, suggesting different epitopes being targeted in both subgroups. Transfer of total IgG from a MOG-IgG positive patient to 2D2 mice did neither enhance disability nor induce functional or histological alterations in the retina.
Keywords:	Neuromyelitis Optica Spectrum Disorder, Optic Nerve, Retina, Myelin-Oligodendrocyte-Glycoprotein, Aquaporin-4, Autoimmunity, Animals, Mice
Source:	Journal of Neuroimmunology
ISSN:	0165-5728
Publisher:	Elsevier
Volume:	342
Page Range:	577194
Date:	15 May 2020
Official Publication:	https://doi.org/10.1016/j.jneuroim.2020.577194
PubMed:	View item in PubMed

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