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| Item Type: | Article |
|---|---|
| Title: | Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses |
| Creators: |
Maglione, M., Kochlamazashvili, G., Eisenberg, T.  ORCID: https://orcid.org/0000-0003-3559-1130, Rácz, B. ORCID: https://orcid.org/0000-0002-1933-5332, Michael, E., Toppe, D., Stumpf, A., Wirth, A., Zeug, A. ORCID: https://orcid.org/0000-0001-9858-5841, Müller, F.E. ORCID: https://orcid.org/0000-0003-0525-0714, Moreno-Velasquez, L. ORCID: https://orcid.org/0000-0001-9735-0039, Sammons, R.P., Hofer, S.J. ORCID: https://orcid.org/0000-0002-0756-0014, Madeo, F., Maritzen, T., Maier, N., Ponimaskin, E. ORCID: https://orcid.org/0000-0002-4570-5130, Schmitz, D. ORCID: https://orcid.org/0000-0003-2741-5241, Haucke, V. ORCID: https://orcid.org/0000-0003-3119-6993 and Sigrist, S.J.
|
| Abstract: | Aging is associated with functional alterations of synapses thought to contribute to age-dependent memory impairment (AMI). While therapeutic avenues to protect from AMI are largely elusive, supplementation of spermidine, a polyamine normally declining with age, has been shown to restore defective proteostasis and to protect from AMI in Drosophila. Here we demonstrate that dietary spermidine protects from age-related synaptic alterations at hippocampal mossy fiber (MF)-CA3 synapses and prevents the aging-induced loss of neuronal mitochondria. Dietary spermidine rescued age-dependent decreases in synaptic vesicle density and largely restored defective presynaptic MF-CA3 long-term potentiation (LTP) at MF-CA3 synapses (MF-CA3) in aged animals. In contrast, spermidine failed to protect CA3-CA1 hippocampal synapses characterized by postsynaptic LTP from age-related changes in function and morphology. Our data demonstrate that dietary spermidine attenuates age-associated deterioration of MF-CA3 synaptic transmission and plasticity. These findings provide a physiological and molecular basis for the future therapeutic usage of spermidine. |
| Keywords: | Aging, Hippocampal CA3 Region, Hippocampal Mossy Fibers, Long-Term Potentiation, Spermidine, Synaptic Transmission, Synaptic Vesicles, Animals, Mice |
| Source: | Scientific Reports |
| ISSN: | 2045-2322 |
| Publisher: | Nature Publishing Group |
| Volume: | 9 |
| Number: | 1 |
| Page Range: | 19616 |
| Date: | 23 December 2019 |
| Official Publication: | https://doi.org/10.1038/s41598-019-56133-3 |
| PubMed: | View item in PubMed |
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