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| Item Type: | Review |
|---|---|
| Title: | Elementary calcium signaling in arterial smooth muscle |
| Creators Name: | Fan, G., Cui, Y., Gollasch, M. and Kassmann, M. |
| Abstract: | Vascular smooth muscle cells (VSMCs) of small peripheral arteries contribute to blood pressure control by adapting their contractile state. These adaptations depend on the VSMC cytosolic Ca(2+) concentration, regulated by complex local elementary Ca(2+) signaling pathways. Ca(2+) sparks represent local, transient, rapid calcium release events from a cluster of ryanodine receptors (RyRs) in the sarcoplasmic reticulum. In arterial SMCs, Ca(2+) sparks activate nearby calcium-dependent potassium channels, cause membrane hyperpolarization and thus decrease the global intracellular [Ca(2+)] to oppose vasoconstriction. Arterial SMC Ca(V)1.2 L-type channels regulate intracellular calcium stores content, which in turn modulates calcium efflux through RyRs. Ca(V)3.2 T-type channels contribute to a minor extend to Ca(2+) spark generation in certain types of arteries. Their localization within cell membrane caveolae is essential. We summarize present data on local elementary calcium signaling (Ca(2+) sparks) in arterial SMCs with focus on RyR isoforms, large-conductance calcium-dependent potassium (BK(Ca)) channels, and cell membrane-bound calcium channels (Ca(V)1.2 and Ca(V)3.2), particularly in caveolar microdomains. |
| Keywords: | Ca(2+) Sparks, Ryanodine Receptors, Ca(V)1.2, Ca(V)3.2, Caveolae, Animals |
| Source: | Channels |
| ISSN: | 1933-6950 |
| Publisher: | Taylor & Francis |
| Volume: | 13 |
| Number: | 1 |
| Page Range: | 505-519 |
| Date: | 4 December 2019 |
| Official Publication: | https://doi.org/10.1080/19336950.2019.1688910 |
| PubMed: | View item in PubMed |
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