Direct lineage reprogramming: harnessing cell plasticity between liver and pancreas

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Item Type:	Article
Title:	Direct lineage reprogramming: harnessing cell plasticity between liver and pancreas
Creators Name:	Ruzittu, S., Willnow, D. and Spagnoli, F.M.
Abstract:	Direct lineage reprogramming of abundant and accessible cells into therapeutically useful cell types holds tremendous potential in regenerative medicine. To date, a number of different cell types have been generated by lineage reprogramming methods, including cells from the neural, cardiac, hepatic, and pancreatic lineages. The success of this strategy relies on developmental biology and the knowledge of cell-fate-defining transcriptional networks. Hepatocytes represent a prime target for β cell conversion for numerous reasons, including close developmental origin, accessibility, and regenerative potential. We present here an overview of pancreatic and hepatic development, with a particular focus on the mechanisms underlying the divergence between the two cell lineages. Additionally, we discuss to what extent this lineage relationship can be exploited in efforts to reprogram one cell type into the other and whether such an approach may provide a suitable strategy for regenerative therapies of diabetes.
Keywords:	Cell Differentiation, Cell Lineage, Cell Plasticity, Cellular Reprogramming, Diabetes Mellitus, Hepatocytes, Insulin-Secreting Cells, Ligands, Liver, Pancreas, Regeneration, Transcription Factors / metabolism, Animals, Mice
Source:	Cold Spring Harbor Perspectives in Biology
ISSN:	1943-0264
Publisher:	Cold Spring Harbor Laboratory Press
Volume:	12
Number:	7
Page Range:	a035626
Date:	July 2020
Additional Information:	Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved
Official Publication:	https://doi.org/10.1101/cshperspect.a035626
External Fulltext:	View full text on PubMed Central
PubMed:	View item in PubMed

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