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| Item Type: | Article |
|---|---|
| Title: | Tissue sodium content and arterial hypertension in obese adolescents |
| Creators Name: | Roth, S., Markó, L., Birukov, A., Hennemuth, A., Kühnen, P., Jones, A., Ghorbani, N., Linz, P., Müller, D.N., Wiegand, S., Berger, F., Kuehne, T. and Kelm, M. |
| Abstract: | Early-onset obesity is known to culminate in type 2 diabetes, arterial hypertension and subsequent cardiovascular disease. The role of sodium (Na(+)) homeostasis in this process is incompletely understood, yet correlations between Na(+) accumulation and hypertension have been observed in adults. We aimed to investigate these associations in adolescents. A cohort of 32 adolescents (13-17 years), comprising 20 obese patients, of whom 11 were hypertensive, as well as 12 age-matched controls, underwent(23) Na-MRI of the left lower leg with a standard clinical 3T scanner. Median triceps surae muscle Na(+) content in hypertensive obese (11.95 mmol/L [interquartile range 11.62-13.66]) was significantly lower than in normotensive obese (13.63 mmol/L [12.97-17.64]; = 0.043) or controls (15.37 mmol/L [14.12-16.08]; = 0.012). No significant differences were found between normotensive obese and controls. Skin Na(+) content in hypertensive obese (13.33 mmol/L [11.53-14.22] did not differ to normotensive obese (14.12 mmol/L [13.15-15.83]) or controls (11.48 mmol/L [10.48-12.80]), whereas normotensive obese had higher values compared to controls ( = 0.004). Arterial hypertension in obese adolescents is associated with low muscle Na(+) content. These findings suggest an early dysregulation of Na(+) homeostasis in cardiometabolic disease. Further research is needed to determine whether this association is causal and how it evolves in the transition to adulthood. |
| Keywords: | Obesity, Sodium, Hypertension, Adolescents, MRI, MR-Spectroscopy |
| Source: | Journal of Clinical Medicine |
| ISSN: | 2077-0383 |
| Publisher: | MDPI |
| Volume: | 8 |
| Number: | 12 |
| Page Range: | 2036 |
| Date: | 21 November 2019 |
| Official Publication: | https://doi.org/10.3390/jcm8122036 |
| PubMed: | View item in PubMed |
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