Regulatory antibodies against GPCR in women ten years after early-onset preeclampsia

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Item Type:	Article
Title:	Regulatory antibodies against GPCR in women ten years after early-onset preeclampsia
Creators Name:	Birukov, A., Muijsers, H.E.C., Heidecke, H., Drost, J.T., Cunnigham, M.W., Kraker, K., Haase, N., Frolova, A., Müller, D.N., Herse, F., Maas, A.H.E.M. and Dechend, R.
Abstract:	Preeclampsia is associated with an increased cardiovascular risk later in life. Anti-GPCR autoantibodies have been shown to contribute to the development of cardiovascular disease. We investigated whether anti-GPCR autoantibodies are elevated in women with a history of early-onset preeclampsia 8-11 years postpartum, and whether they correlate with clinical outcomes. We investigated data from the Preeclampsia Risk EValuation in FEMales cohort, a retrospective matched case-control study. Anti AT1R-, beta1AR-, ETAR-, PAR1- and CXCR3- autoantibodies were determined in 485 samples by using commercially available ELISA. Women with the lowest combined levels of autoantibodies and a history of early preeclampsia had significantly higher SBP, DBP and MAP (all p<0.001) compared to the controls. The individual titer levels of autoantibodies were not different between controls and former early PE groups 8-11 years postpartum. In conclusion, regulatory autoantibodies alone are not sufficient to explain hypertension or other cardiovascular pathologic conditions, but together with other risk factors such as a previous hypertensive pregnancy, lower levels of autoantibodies are associated with increased blood pressure.
Keywords:	Autoantibodies Against GPCR, Preeclampsia, Adverse Pregnancy Outcome, Blood Pressure, Cardiovascular Risk
Source:	Frontiers in Bioscience
ISSN:	1093-9946
Publisher:	Frontiers in Bioscience
Volume:	24
Page Range:	1462-1476
Date:	1 June 2019
Official Publication:	https://doi.org/10.2741/4791
PubMed:	View item in PubMed

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