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| Item Type: | Article |
|---|---|
| Title: | Leptomeningeal and intraparenchymal blood barrier disruption in a MOG-IgG-positive patient |
| Creators Name: | Mohseni, S.H., Skejoe, H.P.B., Wuerfel, J., Paul, F., Reindl, M., Jarius, S. and Asgari, N. |
| Abstract: | BACKGROUND: Recently, pathogenic serum immunoglobulin G (IgG) autoantibodies to myelin oligodendrocyte glycoprotein (MOG) have been detected in a subgroup of patients with central nervous system (CNS) demyelination, including in patients with myelitis. Relatively little is known so far about leptomeningeal involvement in MOG-IgG-positive myelitis. FINDINGS: We report the case of a 30-year-old previously healthy woman presenting with longitudinally extensive transverse myelitis and tetraparesis, in whom both the leptomeningeal barrier and the blood-brain barrier (BBB) were altered, as demonstrated by gadolinium-enhanced MRI during relapse. Blood samples taken at onset and four years later were retrospectively found positive for MOG-IgG. CONCLUSION: Our findings demonstrate that spinal leptomeningeal enhancement (LME) can occur in MOG-IgG-positive encephalomyelitis (EM) and may accompany intraparenchymal BBB breakdown. |
| Source: | Case Reports in Neurological Medicine |
| ISSN: | 2090-6676 |
| Publisher: | Hindawi |
| Volume: | 2018 |
| Page Range: | 1365175 |
| Date: | 9 December 2018 |
| Official Publication: | https://doi.org/10.1155/2018/1365175 |
| PubMed: | View item in PubMed |
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