Collagen I-based scaffolds negatively impact fracture healing in a mouse-osteotomy-model although used routinely in research and clinical application

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Item Type:	Article
Title:	Collagen I-based scaffolds negatively impact fracture healing in a mouse-osteotomy-model although used routinely in research and clinical application
Creators Name:	Lang, A., Kirchner, M., Stefanowski, J., Durst, M., Weber, M.C., Pfeiffenberger, M., Damerau, A., Hauser, A.E., Hoff, P., Duda, G.N., Buttgereit, F., Schmidt-Bleek, K. and Gaber, T.
Abstract:	Although several biomaterials for bone regeneration have been developed in the last decades, clinical application of bone morphogenetic protein 2 is clinically only approved when applied on an absorbable bovine collagen I scaffold (ACS) (Helistat; ACS-H). In research, another ACS, namely Lyostypt (ACS-L) is frequently used as a scaffold in bone-linked studies. Nevertheless, until today, the influence of ACS alone on bone healing remains unknown. Unexpectedly, in vitro studies using ASC-H revealed a suppression of osteogenic differentiation and a significant reduction of cell vitality when compared to ASC-L. In mice, we observed a significant delay in bone healing when applying ACS-L in the fracture gap during femoral osteotomy. The results of our study show for the first time a negative influence of both ACS-H and ACS-L on bone formation demonstrating a substantial need for more sophisticated delivery systems for local stimulation of bone healing in both clinical application and research.
Keywords:	Absorbable Bovine Collagen I Scaffold, Delayed Bone Healing, Non-Collagenous Proteins, Osteotomy Model, Animals, Cattle, Mice
Source:	Acta Biomaterialia
ISSN:	1742-7061
Publisher:	Elsevier
Volume:	86
Page Range:	171-184
Date:	1 March 2019
Official Publication:	https://doi.org/10.1016/j.actbio.2018.12.043
PubMed:	View item in PubMed

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