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| Item Type: | Article |
|---|---|
| Title: | An integrated understanding of the molecular mechanisms how adipose tissue metabolism affects long-term body weight maintenance |
| Creators Name: | Mai, K., Li, L., Wiegand, S., Brachs, M., Leupelt, V., Ernert, A., Kühnen, P., Hübner, N., Robinson, P., Chen, W., Krude, H. and Spranger, J. |
| Abstract: | Life-style based weight loss interventions frequently demonstrate long-term inefficiency and weight regain. Identification of underlying mechanisms and predictors to identify subjects who will benefit from life-style based weight loss strategies is urgently required. We analyzed 143 adults of the randomized Maintain trial (Maintain-Adults) after intended weight loss to identify mechanisms contributing to the regulation of body weight maintenance. Unbiased RNA sequencing of adipose and skeletal muscle biopsies revealed fatty acid metabolism as a key pathway modified by weight loss. Variability of key enzymes of this pathway, estimates of substrate oxidation and specific serum acylcarnitine (AC) species, representing a systemic snapshot of in vivo substrate flux, predicted body weight maintenance (defined as continuous or dichotomized (</≥3% weight regain) variable) 18 months after intended weight loss in the entire cohort. Key results were confirmed in a similar RCT in 137 children and adolescents (Maintain-Children), which investigated the same paradigm in a pediatric cohort. These data suggest that adaption of lipid utilization in response to negative energy balance contributes to subsequent weight maintenance. Particularly a functional role for circulating ACs, which have been suggested to reflect intracellular substrate utilization, as mediators between peripheral energy stores and control of long-term energy homeostasis was indicated. |
| Keywords: | Obesity, Weight Loss Maintenance, Adipose Tissue, Lipid Flux, mRNA Expression Profiling |
| Source: | Diabetes |
| ISSN: | 0012-1797 |
| Publisher: | American Diabetes Association |
| Volume: | 68 |
| Number: | 1 |
| Page Range: | 57-65 |
| Date: | 1 January 2019 |
| Official Publication: | https://doi.org/10.2337/db18-0440 |
| PubMed: | View item in PubMed |
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