Racial differences in neuromyelitis optica spectrum disorder

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Item Type:	Article
Title:	Racial differences in neuromyelitis optica spectrum disorder
Creators Name:	Kim, S.H., Mealy, M.A., Levy, M., Schmidt, F., Ruprecht, K., Paul, F., Ringelstein, M., Aktas, O., Hartung, H.P., Asgari, N., Tsz-Ching, J.L., Siritho, S., Prayoonwiwat, N., Shin, H.J., Hyun, J.W., Han, M., Leite, M.I., Palace, J. and Kim, H.J.
Abstract:	OBJECTIVE: We aimed to evaluate racial differences in the clinical features of neuromyelitis optica spectrum disorder. METHODS: This retrospective review included 603 patients (304 Asian, 207 Caucasian, and 92 Afro-American/Afro-European), who were seropositive for anti-aquaporin-4 antibody, from 6 centers in Denmark, Germany, South Korea, United Kingdom, United States, and Thailand. RESULTS: Median disease duration at last follow-up was 8 years (range 0.3-38.4 years). Asian and Afro-American/Afro-European patients had a younger onset age than Caucasian patients (mean 36, 33, and 44 years, respectively; p < 0.001). During the disease course, Caucasian patients (23%) had a lower incidence of brain/brainstem involvement than Asian (42%) and Afro-American/Afro-European patients (38%) (p < 0.001). Severe attacks (visual acuity ≤0.1 in at least one eye or Expanded Disability Status Scale score ≥6.0 at nadir) at onset occurred more frequently in Afro-American/Afro-European (58%) than in Asian (46%) and Caucasian (38%) patients (p = 0.005). In the multivariable analysis, older age at onset, higher number of attacks before and after immunosuppressive treatment, but not race, were independent predictors of severe motor disabilities at last follow-up. CONCLUSION: A review of a large international cohort revealed that race affected the clinical phenotype, age at onset, and severity of attacks, but the overall outcome was most dependent on early and effective immunosuppressive treatment.
Keywords:	Age of Onset, Disease Progression, Neuromyelitis Optica, Phenotype, Retrospective Studies
Source:	Neurology
ISSN:	0028-3878
Publisher:	American Academy of Neurology
Volume:	91
Number:	22
Page Range:	e2089-e2099
Date:	27 November 2018
Official Publication:	https://doi.org/10.1212/WNL.0000000000006574
External Fulltext:	View full text on PubMed Central
PubMed:	View item in PubMed

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