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| Item Type: | Article |
|---|---|
| Title: | Predicting chronic copper and nickel reproductive toxicity to Daphnia pulex-pulicaria from whole-animal metabolic profiles |
| Creators Name: | Taylor, N.S., Kirwan, J.A., Johnson, C., Yan, N.D., Viant, M.R., Gunn, J.M. and McGeer, J.C. |
| Abstract: | The emergence of omics approaches in environmental research has enhanced our understanding of the mechanisms underlying toxicity; however, extrapolation from molecular effects to whole-organism and population level outcomes remains a considerable challenge. Using environmentally relevant, sublethal, concentrations of two metals (Cu and Ni), both singly and in binary mixtures, we integrated data from traditional chronic, partial life-cycle toxicity testing and metabolomics to generate a statistical model that was predictive of reproductive impairment in a Daphnia pulex-pulicaria hybrid that was isolated from an historically metal-stressed lake. Furthermore, we determined that the metabolic profiles of organisms exposed in a separate acute assay were also predictive of impaired reproduction following metal exposure. Thus we were able to directly associate molecular profiles to a key population response - reproduction, a key step towards improving environmental risk assessment and management. |
| Keywords: | Ecotoxicology, Environmental Risk Assessment, Metal Mixtures, PLS-R, Metabolomics, Mass Spectrometry, Animals, Daphnia |
| Source: | Environmental Pollution |
| ISSN: | 0269-7491 |
| Publisher: | Elsevier |
| Volume: | 212 |
| Page Range: | 325-329 |
| Date: | May 2016 |
| Official Publication: | https://doi.org/10.1016/j.envpol.2016.01.074 |
| PubMed: | View item in PubMed |
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