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VGLUT2 functions as a differential marker for hippocampal output neurons

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Item Type:Article
Title:VGLUT2 functions as a differential marker for hippocampal output neurons
Creators Name:Wozny, C., Beed, P., Nitzan, N., Pössnecker, Y., Rost, B.R. and Schmitz, D.
Abstract:The subiculum is the gatekeeper between the hippocampus and cortical areas. Yet, the lack of a pyramidal cell-specific marker gene has made the analysis of the subicular area very difficult. Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.
Keywords:Channelrhodopsin-2, Entorhinal Cortex, Hippocampus, Subiculum, Synaptic Transmission, VGLUT2, Animals, Mice
Source:Frontiers in Cellular Neuroscience
ISSN:1662-5102
Publisher:Frontiers Media SA
Volume:12
Page Range:337
Date:2 October 2018
Official Publication:https://doi.org/10.3389/fncel.2018.00337
PubMed:View item in PubMed

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