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Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat

Item Type:Article
Title:Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat
Creators Name:Zepeda Mendoza, M.L., Xiong, Z., Escalera-Zamudio, M., Runge, A.K., Thézé, J., Streicker, D., Frank, H.K., Loza-Rubio, E., Liu, S., Ryder, O.A., Samaniego Castruita, J.A., Katzourakis, A., Pacheco, G., Taboada, B., Löber, U., Pybus, O.G., Li, Y., Rojas-Anaya, E., Bohmann, K., Carmona Baez, A., Arias, C.F., Liu, S., Greenwood, A.D., Bertelsen, M.F., White, N.E., Bunce, M., Zhang, G., Sicheritz-Pontén, T. and Gilbert, M.P.T.
Abstract:Adaptation to specialized diets often requires modifications at both genomic and microbiome levels. We applied a hologenomic approach to the common vampire bat (Desmodus rotundus), one of the only three obligate blood-feeding (sanguivorous) mammals, to study the evolution of its complex dietary adaptation. Specifically, we assembled its high-quality reference genome (scaffold N50 = 26.9 Mb, contig N50 = 36.6 kb) and gut metagenome, and compared them against those of insectivorous, frugivorous and carnivorous bats. Our analyses showed a particular common vampire bat genomic landscape regarding integrated viral elements, a dietary and phylogenetic influence on gut microbiome taxonomic and functional profiles, and that both genetic elements harbour key traits related to the nutritional (for example, vitamin and lipid shortage) and non-nutritional (for example, nitrogen waste and osmotic homeostasis) challenges of sanguivory. These findings highlight the value of a holistic study of both the host and its microbiota when attempting to decipher adaptations underlying radical dietary lifestyles.
Keywords:Biological Evolution, Blood, Chiroptera, Diet, Gastrointestinal Microbiome, Genome, Phylogeny, Animals
Source:Nature Ecology & Evolution
Publisher:Nature Publishing Group
Page Range:659-668
Date:April 2018
Official Publication:https://doi.org/10.1038/s41559-018-0476-8
External Fulltext:View full text on PubMed Central
PubMed:View item in PubMed

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