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| Item Type: | Article |
|---|---|
| Title: | Iberis amara extract induces intracellular formation of reactive oxygen species and inhibits colon cancer |
| Creators Name: | Weidner, C., Rousseau, M., Plauth, A., Wowro, S.J., Fischer, C., Abdel-Aziz, H. and Sauer, S. |
| Abstract: | Massively increasing global incidences of colorectal cancer require efficient treatment and prevention strategies. Here, we report unexpected anticancerogenic effects of hydroethanolic Iberis amara extract (IAE), which is known as a widely used phytomedical product for treating gastrointestinal complaints. IAE significantly inhibited the proliferation of HT-29 and T84 colon carcinoma cells with an inhibitory concentration (IC(50) of 6 and 9 μg/ml, respectively, and further generated inhibitory effects in PC-3 prostate and MCF7 breast cancer cells. Inhibition of proliferation in HT-29 cells was associated with a G2/M phase cell cycle arrest including reduced expression of various regulatory marker proteins. Notably, in HT-29 cells IAE further induced apoptosis by intracellular formation of reactive oxygen species (ROS). Consistent with predictions derived from our in vitro experiments, bidaily oral gavage of 50 mg/kg of IAE over 4 weeks resulted in significant inhibition of tumor growth in a mouse HT-29 tumor xenograft model. Taken together, Iberis amara extracts could become useful alternatives for preventing and treating the progression of colon cancer. |
| Keywords: | Brassicaceae, Cell Division, Colonic Neoplasms, Heterografts, Plant Extracts, Reactive Oxygen Species, Tumor Cell Line, Animals, Mice |
| Source: | PLoS ONE |
| ISSN: | 1932-6203 |
| Publisher: | Public Library of Science |
| Volume: | 11 |
| Number: | 4 |
| Page Range: | e0152398 |
| Date: | 6 April 2016 |
| Official Publication: | https://doi.org/10.1371/journal.pone.0152398 |
| PubMed: | View item in PubMed |
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