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| Item Type: | Article |
|---|---|
| Title: | Brain serotonin critically contributes to the biological effects of electroconvulsive seizures |
| Creators Name: | Kronenberg, G., Petermann, M., Dormann, C., Bader, M., Gass, P., Hellweg, R. and Klempin, F. |
| Abstract: | Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2(-/-) mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged the start latency in the elevated O-Maze test, an effect that was abolished in Tph2(-/-) mice. Furthermore, in the absence of 5-HT, the ECS-induced increase in adult neurogenesis and in brain-derived neurotrophic factor signaling in the hippocampus were significantly reduced. Our results indicate that brain 5-HT critically contributes to the neurobiological responses to ECS. |
| Keywords: | Neurogenesis, BDNF, TPH2, Depression, Antidepressants, Animals, Mice |
| Source: | European Archives of Psychiatry and Clinical Neuroscience |
| ISSN: | 0940-1334 |
| Publisher: | Springer / Steinkopff |
| Volume: | 268 |
| Number: | 8 |
| Page Range: | 861-864 |
| Date: | December 2018 |
| Additional Information: | Copyright© Springer-Verlag GmbH Germany, part of Springer Nature 2018 |
| Official Publication: | https://doi.org/10.1007/s00406-018-0924-0 |
| PubMed: | View item in PubMed |
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