Auto-antibodies against the angiotensin II type I receptor in women with uteroplacental acute atherosis and preeclampsia at delivery and several years postpartum

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Item Type:	Article
Title:	Auto-antibodies against the angiotensin II type I receptor in women with uteroplacental acute atherosis and preeclampsia at delivery and several years postpartum
Creators Name:	Rieber-Mohn, A.B., Sugulle, M., Wallukat, G., Alnæs-Katjavivi, P., Leite Størvold, G., Bolstad, N., Redman, C.W., Dechend, R. and Staff, A.C.
Abstract:	BACKGROUND: Uteroplacental acute atherosis is a pregnancy-specific lesion resembling early stages of atherosclerosis found frequently in preeclampsia. Preeclampsia is associated with an increased risk for future maternal atherosclerotic cardiovascular disease. The renin-angiotensin-system plays a role both in atherosclerosis and in preeclampsia. Circulating agonistic autoantibodies at the angiotensin-II type 1 receptor (AT(1)-AA) are increased in preeclampsia. We hypothesized an association between AT(1)-AA at delivery and postpartum with acute atherosis in pregnancy. MATERIAL AND METHODS: Maternal serum and decidua basalis tissue was collected at elective cesarean section (n = 41; 24 preeclampsia, 17 normotensive controls). Circulating AT(1)-AA were detected by a bioassay using spontaneously beating rat cardiomyocytes at delivery (n = 41) and 5-8 years postpartum in a subgroup (n = 10). Decidual acute atherosis was assessed by immunohistochemistry. RESULTS: Significantly less normotensive controls (18%; 3/17) than women with preeclampsia (58%; 14/24) were AT(1)-AA positive at delivery, p<0.01. Uteroplacental acute atherosis and circulating AT-AA at delivery were not significantly correlated. Postpartum, 2 prior preeclamptic women had circulating AT(1)-AA, both without acute atherosis in pregnancy. CONCLUSIONS: Our results confirm that circulating AT(1)-AA are present significantly more often in preeclampsia than in normotensive pregnancy, however without association to acute atherosis. Whether circulating maternal AT(1)-AA or acute atherosis target young women at increased long-term cardiovascular risk warrants further investigations.
Keywords:	Autoantibodies, Acute Atherosis, Cardiovascular Disease, Preeclampsia, Renin-Angiotensin System
Source:	Journal of Reproductive Immunology
ISSN:	0165-0378
Publisher:	Elsevier
Volume:	128
Page Range:	23-29
Date:	August 2018
Official Publication:	https://doi.org/10.1016/j.jri.2018.05.008
PubMed:	View item in PubMed

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