Helmholtz Gemeinschaft


Metabolic barriers to weight gain in patients with anorexia nervosa: a young adult case report

[thumbnail of 17470oa.pdf]
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader

Item Type:Article
Title:Metabolic barriers to weight gain in patients with anorexia nervosa: a young adult case report
Creators Name:Haas, V., Stengel, A., Mähler, A., Gerlach, G., Lehmann, C., Boschmann, M., de Zwaan, M. and Herpertz, S.
Abstract:BACKGROUND: Over-proportionally high energy requirements in some patients with anorexia nervosa (AN) have been reported, but their exact origin remains unclear. OBJECTIVE: To objectively measure metabolic alterations in an AN patient with high energy requirements as judged by clinical observation. MATERIALS AND METHODS: We present the case of a young woman with AN (index patient, IP; 19 years, admission BMI 13.9 kg/m(2)). After 3 months of treatment at BMI 17.4 kg/m(2), we assessed her resting energy expenditure (REE), respiratory exchange ratio (RER), diet-induced thermogenesis (DIT), seated non-exercise physical activity (NEPA in Volt by infrared sensors), and exercise activity thermogenesis (EAT) in a metabolic chamber; body composition (bioimpedance analysis), energy intake (15d-food protocol), physical activity (accelerometry) and endocrine parameters. The IP was compared for REE, RER, DIT and seated NEPA to six AN patients (AN-C) and four healthy women (HC-1), and for EAT to another six healthy women (HC-2). RESULTS: Our IP showed high REE (110% of predicted REE according to Harris & Benedict) and high seated NEPA (47% increase over AN-C, 40% over HC-1), whereas DIT (IP: 78 vs. HC-1: 145 ± 51 kJ/180 min) and EAT (IP: 157 vs. HC-2: 235 ± 30 kJ/30 min) were low, when compared with HC. The other AN patients showed a lower REE (AN: 87 ± 2% vs. HC: 97 ± 2% predicted) at increased DIT (AN: 187 ± 91 vs. HC: 145 ± 51 kJ/180 min) when compared with HC. RER of the IP was low (IP: 0.72 vs. 0.77 in AN-C; 0.77 in HC-1 and 0.80 in HC-2). CONCLUSIONS: Complex and variable disturbances of energy metabolism might exist in a subgroup of patients with AN during refeeding, which could lead to unexpectedly high energy requirements. Future studies need to confirm the existence, and investigate the characteristics and prevalence of this subgroup.
Keywords:Anorexia Nervosa, Energy Requirements, Energy Metabolism, Metabolic Chamber, Seated Non-Exercise Physical Activity
Source:Frontiers in Psychiatry
Publisher:Frontiers Media SA
Page Range:199
Date:May 2018
Official Publication:https://doi.org/10.3389/fpsyt.2018.00199
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library