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| Item Type: | Article |
|---|---|
| Title: | Single synaptic inputs drive high-precision action potentials in parvalbumin expressing GABA-ergic cortical neurons in vivo |
| Creators Name: | Jouhanneau, J.S., Kremkow, J. and Poulet, J.F.A. |
| Abstract: | A defining feature of cortical layer 2/3 excitatory neurons is their sparse activity, often firing in singlets of action potentials. Local inhibitory neurons are thought to play a major role in regulating sparseness, but which cell types are recruited by single excitatory synaptic inputs is unknown. Using multiple, targeted, in vivo whole-cell recordings, we show that single EPSPs have little effect on the firing rates of excitatory neurons and somatostatin-expressing GABA-ergic inhibitory neurons but evoke precisely timed action potentials in parvalbumin-expressing inhibitory neurons. Despite a EPSP decay time of 7.8 ms, the evoked action potentials were almost completely restricted to the EPSP rising phase (~0.5 ms). Evoked parvalbumin-expressing neuron action potentials go on to inhibit the local excitatory network, thus providing a pathway for single spike evoked disynaptic inhibition which may enforce sparse and precisely timed cortical signaling. |
| Keywords: | Action Potentials, Cerebral Cortex, GABAergic Neurons, Gamma-Aminobutyric Acid, Inbred C57BL, Mice, Neural Inhibition, Parvalbumins, Patch-Clamp Techniques, Photons, Software, Somatostatin, Synapses, Animals, Mice |
| Source: | Nature Communications |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Volume: | 9 |
| Number: | 1 |
| Page Range: | 1540 |
| Date: | 18 April 2018 |
| Official Publication: | https://doi.org/10.1038/s41467-018-03995-2 |
| PubMed: | View item in PubMed |
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