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| Item Type: | Article |
|---|---|
| Title: | Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth |
| Creators: |
Pan, Y., Xiong, M., Chen, R., Ma, Y., Corman, C., Maricos, M.  ORCID: https://orcid.org/0000-0002-3873-6887, Kindler, U. ORCID: https://orcid.org/0000-0001-9676-6323, Semtner, M. ORCID: https://orcid.org/0000-0001-9379-9023, Chen, Y.H., Dahiya, S. and Gutmann, D.H. ORCID: https://orcid.org/0000-0002-3127-5045
|
| Abstract: | Pediatric low-grade gliomas (LGGs) frequently do not engraft in immunocompromised mice, limiting their use as an experimental platform. In contrast, murine Neurofibromatosis-1 (Nf1) optic LGG stem cells (o-GSCs) form glioma-like lesions in wild-type, but not athymic, mice following transplantation. Here, we show that the inability of athymic mice to support o-GSC engraftment results from impaired microglia/macrophage function, including reduced expression of Ccr2 and Ccl5, both of which are required for o-GSC engraftment and Nf1 optic glioma growth. Impaired Ccr2 and Ccl5 expression in athymic microglia/macrophages was restored by T-cell exposure, establishing T-cell-microglia/macrophage interactions as critical stromal determinants that support NF1 LGG growth. |
| Keywords: | Tumor Microenvironment, Stroma, Monocyte, Chemokines, Animals, Mice |
| Source: | Genes & Development |
| ISSN: | 0890-9369 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Volume: | 32 |
| Number: | 7-8 |
| Page Range: | 491-496 |
| Date: | 9 April 2018 |
| Official Publication: | https://doi.org/10.1101/gad.310797.117 |
| External Fulltext: | View full text on PubMed Central |
| PubMed: | View item in PubMed |
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