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| Item Type: | Review |
|---|---|
| Title: | Methods for lineage tracing on the organism-wide level |
| Creators Name: | Spanjaard, B. and Junker, J.P. |
| Abstract: | Determining the lineage origin of cell types is a major goal in developmental biology. Furthermore, lineage tracing is a powerful approach for understanding the origin of developmental defects as well as the origin of diseases such as cancer. There is now a variety of complementary approaches for identifying lineage relationships, ranging from direct observation of cell divisions by light microscopy to genetic labeling of cells using inducible recombinases and fluorescent reporters. A recent development, and the main topic of this review article, is the use of high-throughput sequencing data for lineage analysis. This emerging approach holds the promise of increased multiplexing capacity, allowing lineage analysis of large cell numbers up to the organism-wide level combined with simultaneous transcription profiling by single cell RNA sequencing. |
| Keywords: | Cell Lineage |
| Source: | Current Opinion in Cell Biology |
| ISSN: | 0955-0674 |
| Publisher: | Elsevier / Current Biology |
| Volume: | 49 |
| Page Range: | 16-21 |
| Date: | December 2017 |
| Additional Information: | Copyright © 2017 Elsevier |
| Official Publication: | https://doi.org/10.1016/j.ceb.2017.11.004 |
| PubMed: | View item in PubMed |
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